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However, disabling motor complications occur in the late stages of PD with the most common effect that includes onset of on-off phenomena and abnormal involuntary movements called dyskinesia (Jankovic, 2002); hence the need for better, perhaps more physiologically based therapy for this complex disorder remains. Most patients treated with L-dopa develop fluctuation in motor performance. After 3-5 years of treatment one-third, after 5-7 years about half and after 10-12 years nearly all patients suffer from the motor fluctuation (Rinne, 1983).

Therefore, any novel antioxidant molecules designed as potential neuroprotective treatment in acute or chronic neurological disorders such as PD should have the mandatory prerequisite that they can cross the BBB after systemic administration. REFERENCES Bank, R. G. , Henderson, J. R. and Pratt, J. M. (1968). Reaction of gases in solution. III. Some reactions of nitric oxide and transition metal complexes, J. Chem. Soc. A, 2886-2890. 40 G. A. Qureshi et al. , et al. (2002). Early diagnosis of Parkinson's disease, /.

A great deal of interest has been focused on the possibility that oxidative demage plays an important role in the pathogenesis of various degenerative disorders (Smith et al, 1991; Dexter et al, 1994; Koroshetz et al, 1994; Qureshi et al, 1997). Hence, the role of free radical in cell death induced by activation of EAA receptors is an area of expanding interest (Kontos, 1989; Halliwell, 1992; Coyle et al, 1993; Qureshi et al, 1995; Qureshi et al, 2003b). Biological systems have developed a comprehensive array of defense mechanisms to protect against free radicals.

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